Modification of PEGylated enzyme with glutaraldehyde can enhance stability while avoiding intermolecular crosslinking
نویسندگان
چکیده
منابع مشابه
Modification of PEGylated enzyme with glutaraldehyde can enhance stability while avoiding intermolecular crosslinking.
We demonstrate an enzyme stabilization approach whereby a model enzyme is PEGylated, followed by controlled chemical modification with glutaraldehyde. Using this stabilization strategy, size increases and aggregation due to intermolecular crosslinking are avoided. Immediately following synthesis, the PEGylated enzyme with and without glutaraldehyde modification possessed specific activities of ...
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ژورنال
عنوان ژورنال: RSC Adv.
سال: 2014
ISSN: 2046-2069
DOI: 10.1039/c4ra03809f